Wu E, Wu C, Jia K, Zhou s, and Sun L*. HSPA8 inhibitors augment cancer chemotherapeutic effectiveness via potentiating necroptosis. Mol Biol Cell, 2024, doi: 10.1091/mbc.E24-04-0194. PDF
Marion C. Bonnet* and Liming Sun, Editorial: Necroptosis: from bench to bedside. Front. Immunol., 19 June 2024. doi.org/10.3389/fimmu.2024.1441901. PDF
Wu E#, He W#, Wu C, Chen Z, Zhou S, Wu X, Hu Z, Jia K, Pan J, Wang L, Qin J, Liu D, Lu J, Wang H, Li J, Wang S, and Sun L *. HSPA8 acts as an amyloidase to suppress necroptosis by inhibiting and reversing functional amyloid formation. Cell Research, 2023, 33, 851-866.
*This work was highlighted in Cell Research by Bart Tummers "RHIMoving fibrils of death". PDF
Sun L*. Amyloids as kinase signalling platforms. Nature Reviews Molecular Cell Biology, 2023, 24(2), 85. PDF
Zhu X, Yang N, Yang Y, Yuan F, Yu D, Zhang Y, Shu Z, Nan N, Hu H, Liu X, Chen S, Sun L* and Wang H*.Spontaneous necroptosis and autoinflammation are blocked by an inhibitory phosphorylation on MLKL during neonatal development. Cell Research. 2021, 32(4), 407-410
*Story of this work was selected by Faculty of 1000 Biology. PDF
Zhou S, Zhang W, Cai G, Ding Y, Wei C, Li S, Yang Y, Qin J, Liu D, Zhang H, Shao X, Wang X, Wang H, Yang W, Wang H, Chen S, Hu P* and Sun L*. Myofiber necroptosis promotes muscle stem cell proliferation via releasing Tenascin-C during regeneration. Cell Research. 2020, 30(12), 1063–1077.
*Cover story. Story of this work was selected by Faculty of 1000 Biology. PDF
Yang D, Sun Y, Chen J, Zhang Y, Fan S, Huang M, Xie X, Cai Y, Shang Y, Gui T, Sun L, Hu J, Dong J, Yeap LS, Wang X, Xiao W, Meng FL*. REV7 is required for processing AID initiated DNA lesions in activated B cells. Nat Commun, 2020, 11(1), 2812. PDF
Zhang J, Yang Y, Zhou S, He X, Cao X, Wu C, Hu H, Qin J, Wei G, Wang H, Liu S* and Sun L*. Membrane-bound TNF mediates microtubule-targeting chemotherapeutics-induced cancer cytolysis via juxtacrine inter-cancer-cell death signaling. Cell Death & Differ, 2020, 27(5), 1569–1587. PDF
Ran Y, Su Y, Sun L, He S, Meng L, Liao D, Ma Y, Liu C, Li S, Ruan H, Lei X, Wang X* and Zhang Z*. Discovery of a Highly Potent, Selective, and Metabolically Stable Inhibitor of Receptor-Interacting Protein 1 (RIP1) for the Treatment of Systemic Inflammatory Response Syndrome. J Med Chem, 2017, 60(3), 972-986. PDF
Zhang J, Yang Y, He W, Sun L*. Necrosome core machinery: MLKL. Cellular and Molecular Life Sciences, 2016, 73(11-13), 2153-2163. PDF
Sun L* and Wang X. A new kind of cell suicide: mechanisms and functions of programmed necrosis. Trends in biochemical sciences. 2014, 39(12), 587-593. PDF
Su L, Quade B, Wang H, Sun L, Wang X, Rizo J*. (2014) A Plug Release Mechanism for Membrane Permeation by MLKL. Structure, 2014, 22(10): 1489-1500. PDF
Wang H, Sun L, Su L, Rizo J, Liu L, Wang LF, Wang FS, Wang X*.Mixed lineage kinase domain-like protein MLKL causes necrotic membrane disruption upon phosphorylation by RIP3. Mol Cell, 2014, 54, 133-146.
*Cover story. Story of this work was selected by Faculty of 1000 Biology. PDF
Sun L, Wang H, Wang Z, He S, Chen S, Liao D, Wang L, Yan J, Liu W, Lei X*, and Wang X*. Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase. Cell, 2012, 148, 213-227.
*Research of this work was highlighted in Cell, Nature Reviews Molecular Cell Biology, and Chem. & Eng. News. Story of this work was selected by Faculty of 1000 Biology. PDF
Liao D, Sun L, Liu W, He S, Wang X, Lei X*. Necrosulfonamide Inhibits Necroptosis by Selectively Targeting the Mixed Lineage Kinase Domain-like Protein. Med. Chem. Commun., 2014, 5, 333-337. PDF
Li S, Zhang L, Yao Q, Li L, Dong N, Rong J, Gao W, Ding X, Sun L, Chen X, Chen S* and Shao F*. Pathogen blocks host death receptor signalling by arginine GlcNAcylation of death domains. Nature, 2013, 501, 242-6. PDF
Hildebrand JM, Sun L, Silke J*. An appointment with death,生死有时: 2013 Cold Spring Harbor Asia meeting ‘Mechanisms and Functions of Non- Apoptotic Cell Death’. Cell Death & Differ, 2013, 20, 1593-4. PDF
Sun L, Wang H, Hu J, Han J, Matsunami H, Luo M*. Guanylyl cyclase-D in the olfactory CO2 neurons is activated by bicarbonate. Proc Natl Acad Sci U S A, 2009, 106, 2041-2046. PDF
Luo M*, Sun L*and Hu J*. Neural detection of gases--carbon dioxide, oxygen--in vertebrates and invertebrates. Curr Opin Neurobiol, 2009, 19, 354-361.
*Corresponding author. PDF
