Publications

Publications

  1. Zhang W, Wang Y, Zuo C, He J, Ma X, Wu H, Lan B, Kong D, Chen L, Wei G, Yang N, Fu Y, Liu D, Liu Y* and Sun L*. Long-term confinement triggers RIPK3-independent necroptosis in amoeboid cancer cells to shape tumor evolution. Developmental Cell, 2026, 61(10), 1952-1968.  PDF
    Previewed in Developmental Cell: Squeezed to death: Mechanical control of MLKL beyond RIPK3 Preview PDF
    This study was selected by Cell Press for an official press release: https://www.eurekalert.org/news-releases/1147008 
  2. Zhang N, Huang X, Lu S, Zou Y, Sun G, Zhang W, Lu H, Wang L, Lu X, Zhang Z, Cheng C, You S, Zhang H, Zhang Y, Wang P, Zhou P, Luo J, Chen Y, Wu F, Guo J, Ning A, Guo Y, Cao L, Sun L*and Sun Y*.Lactate couples metabolic state to necroptosis across pathological and physiological conditions. Cell Metabolism, 2026, 38(10), 2036-2053.PDF
  3. Abu-Remaileh M, Chan C, Chen L, Demirer G, Fiszbein A, Jug F, Lechuga-Vieco A, Luisier R, Pagan J, Sabari B, Shao S, Sun L &Żylicz J. Visions of the future of molecular cell biology[J]. Nature Reviews Molecular Cell Biology, 2025, 26(10): 735-740.  PDF
  4. Arama E, Cosentino K, Czabotar P, Gan B, Hartland E, Jiang X, Kagan J, Nagata S, Schroder K, Sun L, Xu D & Yuan J. Towards a molecular and structural definition of cell death[J]. Nature Structural & Molecular Biology, 2025, 32(10): 1854-1858.  PDF
  5. Wu E, Wu C, Jia K, Zhou s, and Sun L*. HSPA8 inhibitors augment cancer chemotherapeutic effectiveness via potentiating necroptosis[J]. Molecular Biology of the Cell, 2024, 35(8): ar108.  PDF
  6. Bonnet MC and Sun L. Editorial: Necroptosis: from bench to bedside. Front. Immunol. , 19 June 2024. 15:1441901. doi: 10.3389/fimmu.2024.1441901. PDF
  7. Wu E#, He W#, Wu C, Chen Z, Zhou S, Wu X, Hu Z, Jia K, Pan J, Wang L, Qin J, Liu D, Lu J, Wang H, Li J, Wang S, and Sun L *. HSPA8 acts as an amyloidase to suppress necroptosis by inhibiting and reversing functional amyloid formation[J]. Cell Research, 2023, 33(11): 851-866.
    *This work was highlighted in Cell Research by Bart Tummers "RHIMoving fibrils of death".  PDF
  8. Sun L*. Amyloids as kinase signalling platforms. Nature Reviews Molecular Cell Biology, 2023, 24(2), 85. PDF
  9. Zhu X, Yang N, Yang Y, Yuan F, Yu D, Zhang Y, Shu Z, Nan N, Hu H, Liu X, Chen S, Sun L* and Wang H*. Spontaneous necroptosis and autoinflammation are blocked by an inhibitory phosphorylation on MLKL during neonatal development[J]. Cell Research, 2022, 32(4): 407-410.
    *Story of this work was selected by Faculty of 1000 Biology.  PDF
  10. Zhou S, Zhang W, Cai G, Ding Y, Wei C, Li S, Yang Y, Qin J, Liu D, Zhang H, Shao X, Wang X, Wang H, Yang W, Wang H, Chen S, Hu P* and Sun L*. Myofiber necroptosis promotes muscle stem cell proliferation via releasing Tenascin-C during regeneration. Cell Research. 2020, 30(12), 1063–1077.
    *Cover story. Story of this work was selected by Faculty of 1000 Biology. PDF
  11. Yang D, Sun Y, Chen J, Zhang Y, Fan S, Huang M, Xie X, Cai Y, Shang Y, Gui T, Sun L, Hu J, Dong J, Yeap LS, Wang X, Xiao W, Meng FL*. REV7 is required for processing AID initiated DNA lesions in activated B cells. Nat Commun, 2020, 11(1), 2812. PDF
  12. Zhang J, Yang Y, Zhou S, He X, Cao X, Wu C, Hu H, Qin J, Wei G, Wang H, Liu S* and Sun L*. Membrane-bound TNF mediates microtubule-targeting chemotherapeutics-induced cancer cytolysis via juxtacrine inter-cancer-cell death signaling. Cell Death & Differ, 2020, 27(5), 1569–1587. PDF
  13. Ran Y, Su Y, Sun L, He S, Meng L, Liao D, Ma Y, Liu C, Li S, Ruan H, Lei X, Wang X* and Zhang Z*. Discovery of a Highly Potent, Selective, and Metabolically Stable Inhibitor of Receptor-Interacting Protein 1 (RIP1) for the Treatment of Systemic Inflammatory Response Syndrome. J Med Chem, 2017, 60(3), 972-986. PDF
  14. Zhang J, Yang Y, He W, Sun L*. Necrosome core machinery: MLKL. Cellular and Molecular Life Sciences, 2016, 73(11-13), 2153-2163. PDF
  15. Sun L* and Wang X. A new kind of cell suicide: mechanisms and functions of programmed necrosis. Trends in biochemical sciences. 2014, 39(12), 587-593. PDF
  16. Su L, Quade B, Wang H, Sun L, Wang X, Rizo J*. (2014) A Plug Release Mechanism for Membrane Permeation by MLKL. Structure, 2014, 22(10): 1489-1500. PDF
  17. Wang H, Sun L, Su L, Rizo J, Liu L, Wang LF, Wang FS, Wang X*.Mixed lineage kinase domain-like protein MLKL causes necrotic membrane disruption upon phosphorylation by RIP3. Mol Cell, 2014, 54, 133-146.
    *Cover story. Story of this work was selected by Faculty of 1000 Biology. PDF
  18. Sun L, Wang H, Wang Z, He S, Chen S, Liao D, Wang L, Yan J, Liu W, Lei X*, and Wang X*. Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase. Cell, 2012, 148, 213-227.
    *Research of this work was highlighted in Cell, Nature Reviews Molecular Cell Biology, and Chem. & Eng. News. Story of this work was selected by Faculty of 1000 Biology. PDF
  19. Liao D, Sun L, Liu W, He S, Wang X, Lei X*. Necrosulfonamide Inhibits Necroptosis by Selectively Targeting the Mixed Lineage Kinase Domain-like Protein. Med. Chem. Commun., 2014, 5, 333-337. PDF
  20. Li S, Zhang L, Yao Q, Li L, Dong N, Rong J, Gao W, Ding X, Sun L, Chen X, Chen S* and Shao F*. Pathogen blocks host death receptor signalling by arginine GlcNAcylation of death domains. Nature, 2013, 501, 242-6. PDF
  21. Hildebrand JM, Sun L, Silke J*. An appointment with death,生死有时: 2013 Cold Spring Harbor Asia meeting ‘Mechanisms and Functions of Non- Apoptotic Cell Death’. Cell Death & Differ, 2013, 20, 1593-4. PDF
  22. Sun L, Wang H, Hu J, Han J, Matsunami H, Luo M*. Guanylyl cyclase-D in the olfactory CO2 neurons is activated by bicarbonate. Proc Natl Acad Sci U S A, 2009, 106, 2041-2046. PDF
  23. Luo M*, Sun L*and Hu J*. Neural detection of gases--carbon dioxide, oxygen--in vertebrates and invertebrates. Curr Opin Neurobiol, 2009, 19, 354-361.
    *Corresponding author. PDF